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Basic Principles
Regulation within living organisms primarily involves the transcription of DNA into RNA and the translation of RNA into proteins. Nucleic acid drugs utilizing the siRNA pathway mainly function by inhibiting or degrading endogenous mRNA to reduce protein expression levels. In contrast, nucleic acid drugs in the form of mRNA achieve therapeutic goals by introducing exogenous mRNA to induce the overexpression of specific proteins.
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Quick response
The mRNA sequence can be modified in as little as a few weeks to adapt to new pathogens or disease targets. This is particularly advantageous in responding to sudden infectious diseases or pathogens with high mutation rates.
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High Safety Profile
mRNA does not enter the cell nucleus and does not integrate into the host genome DNA. It has a short half-life, and its metabolic byproducts are natural nucleotides, reducing long-term risks.
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Strong Immune Activation Capability
It can induce both cellular and humoral immune responses, making it suitable for vaccines and immunotherapy.
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Infectious Disease Vaccine
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Cancer vaccine
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immunity therapy
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Tumor
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Metabolic disease
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Rare disease
